Abstract

Background:

A composite measure that assesses both cognitive and functional abilities in Parkinson’s disease (PD) would be useful for diagnosing mild cognitive impairment (MCI) and PD dementia (PDD) and as an outcome measure in randomized controlled trials. The Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) was designed to assess both cognition and basic-instrumental activities of daily living in Alzheimer’s disease but has not yet been validated in PD.

Objective:

To validate the CDR-SOB as a composite cognitive-functional measure for PD patients, as well as to assess its sensitivity to change.

Methods:

The CDR-SOB and a comprehensive cognitive and functional battery was administered to 101 PD patients at baseline (39 normal cognition [NC], 41 MCI and 21 PDD by expert consensus panel), and re-administered to 64 patients after 1-2 years follow-up (32 NC and 32 cognitive impairment [CI] at baseline).

Results:

Cross-sectionally, CDR-SOB and domain scores were correlated with corresponding neuropsychological or functional measures and were significantly different between cognitive subgroups both at baseline and at follow-up. In addition, CDR-SOB ROC curves distinguished between normal cognition and dementia with high sensitivity, but did not distinguish well between NC and MCI. Longitudinal changes in the CDR-SOB and domain scores were not significant and were inconsistent in predicting change in commonly-used cognitive and functional tests.

Conclusion:

The CDR-SOB detects dementia-level cognitive impairment in PD but may not be appropriate for predicting longitudinal combined cognitive-functional changes in patients without significant cognitive impairment at baseline.

中文翻译：

---

帕金森病临床痴呆评定量表总和的心理测量学特性

摘要

背景：

评估帕金森病 (PD) 的认知和功能能力的复合测量将有助于诊断轻度认知障碍 (MCI) 和 PD 痴呆 (PDD)，并作为随机对照试验的结果测量。临床痴呆评定量表总和 (CDR-SOB) 旨在评估阿尔茨海默病患者日常生活的认知和基本仪器活动，但尚未在 PD 中得到验证。

客观的：

验证 CDR-SOB 作为 PD 患者的复合认知功能测量，以及评估其对变化的敏感性。

方法：

CDR-SOB 和综合认知和功能电池组在基线时对 101 名 PD 患者（39 名正常认知 [NC]、41 名 MCI 和 21 名专家共识小组的 PDD）进行了管理，并在 1-2 年后重新管理了 64 名患者随访（基线时 32 例 NC 和 32 例认知障碍 [CI]）。

结果：

横断面，CDR-SOB 和领域得分与相应的神经心理学或功能测量相关，并且在基线和随访时认知亚组之间存在显着差异。此外，CDR-SOB ROC 曲线以高灵敏度区分正常认知和痴呆，但不能很好地区分 NC 和 MCI。CDR-SOB 和领域评分的纵向变化不显着，并且在预测常用认知和功能测试的变化方面不一致。

结论：

CDR-SOB 检测 PD 中的痴呆水平认知障碍，但可能不适用于预测基线时没有明显认知障碍的患者的纵向联合认知功能变化。