Background:Financial capacity is often one of the first instrumental activities of daily living to be affected in cognitively normal (CN) older adults who later progress to amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. Objective:The objective of this study was to investigate the association between financial capacity and regional cerebral tau. Methods:Cross-sectional financial capacity was assessed using the Financial Capacity Instrument –Short Form (FCI-SF) in 410 CN, 199 MCI, and 61 AD dementia participants who underwent flortaucipir tau positron emission tomography from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Linear regression models with backward elimination were used with FCI-SF total score as the dependent variable and regional tau and tau-amyloid interaction as predictors of interest in separate analyses. Education, age sex, Rey Auditory Verbal Learning Test Total Learning, and Trail Making Test B were used as covariates. Results:Significant associations were found between FCI-SF and tau regions (entorhinal: p < 0.001; inferior temporal: p < 0.001; dorsolateral prefrontal: p = 0.01; posterior cingulate: p = 0.03; precuneus: p < 0.001; and supramarginal gyrus: p = 0.005) across all participants. For the tau-amyloid interaction, significant associations were found in four regions (amyloid and dorsolateral prefrontal tau interaction: p = 0.005; amyloid and posterior cingulate tau interaction: p = 0.005; amyloid and precuneus tau interaction: p < 0.001; and amyloid and supramarginal tau interaction: p = 0.002). Conclusion:Greater regional tau burden was modestly associated with financial capacity impairment in early-stage AD. Extending this work with longitudinal analyses will further illustrate the utility of such assessments in detecting clinically meaningful decline, which may aid clinical trials of early-stage AD.

中文翻译：

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认知正常老年人、轻度认知障碍和阿尔茨海默病痴呆的财务能力和区域脑 Tau

背景：经济能力通常是认知正常 (CN) 老年人日常生活中最先受到影响的工具性活动之一，这些老年人后来发展为遗忘性轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 痴呆。目的：本研究的目的是调查财务能力与区域脑 tau 之间的关联。方法：使用财务能力工具 – 简表 (FCI-SF) 对 410 名 CN、199 名 MCI 和 61 名接受阿尔茨海默病神经影像学计划 (ADNI) 的 flortaucipir tau 正电子发射断层扫描的 AD 痴呆参与者的横截面财务能力进行了评估. 使用具有向后消除的线性回归模型，FCI-SF 总分作为因变量，区域 tau 和 tau-淀粉样蛋白相互作用作为单独分析中感兴趣的预测因子。教育、年龄性别、Rey 听觉语言学习测试总学习和 Trail Making 测试 B 被用作协变量。结果：FCI-SF 和 tau 区之间存在显着关联（内嗅区：p < 0.001；颞下区：p < 0.001；背外侧前额叶：p = 0.01；后扣带回：p = 0.03；楔前叶：p < 0.001；缘上回: p = 0.005) 所有参与者。对于 tau-淀粉样蛋白相互作用，在四个区域发现了显着关联（淀粉样蛋白和背外侧前额叶 tau 相互作用：p = 0.005；淀粉样蛋白和后扣带回 tau 相互作用：p = 0.005；淀粉样蛋白和楔前叶 tau 相互作用：p < 0.001；淀粉样蛋白和超边缘 tau 相互作用：p = 0.002）。结论：更大的区域 tau 负担与早期 AD 的财务能力受损适度相关。通过纵向分析扩展这项工作将进一步说明此类评估在检测具有临床意义的衰退方面的效用，这可能有助于早期 AD 的临床试验。