Background:The relationship between midlife dietary habits and risk of dementia remains unclear. Objective:To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life. Methods:This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45–64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression. Results:Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (OR = 0.43 (95%CI = 0.20–0.93)), third (OR = 0.22 (95%CI = 0.09–0.54)), and highest quartiles (OR = 0.39 (95%CI = 0.18–0.86)) for fish; the third (OR = 0.39(95%CI = 0.16–0.92)) and highest quartiles (OR = 0.44(95%CI = 0.19–0.98)) for eicosapentaenoic acid (EPA); the second (OR = 0.39(95%CI = 0.18–0.84)), third (OR = 0.30(95%CI = 0.13–0.70)), and highest quartiles (OR = 0.28(95%CI = 0.12–0.66)) for docosahexaenoic acid (DHA); and the third (OR = 0.36 (95%CI = 0.16–0.85)) and highest quartiles (OR = 0.42 (95%CI = 0.19–0.95)) for docosapentaenoic acid (DPA). Conclusion:High intake of fish in midlife might aid in preventing dementia.

中文翻译：

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膳食鱼与中年和晚年痴呆症的多不饱和脂肪酸摄入量之间的关联：JPHC Saku 心理健康研究

背景：中年饮食习惯与痴呆风险之间的关系尚不清楚。目的：研究中年食用鱼与n-3多不饱和脂肪酸（PUFA）摄入量与晚年痴呆风险之间的关系。方法：这项基于人群的队列研究评估了 1,127 名参与者（1995 年 45-64 岁）的食物频率（1995 年和 2000 年的平均摄入量）和认知（2014-2015 年）。我们使用逻辑回归分析来计算痴呆症和轻度认知障碍 (MCI) 诊断的优势比 (ORs)，用于鱼类消费四分位数、富含 PUFA 的鱼类、总 n-3 PUFA、总 n-6 PUFA、PUFA 类型和n-3/n-6 PUFA 比率。估计的 OR 值根据年龄进行了调整；性别; 教育; 吸烟状况；饮酒频率；体力活动; 癌症病史、心肌梗塞病史、和糖尿病；和抑郁症。结果：在第二个 (OR = 0.43 (95%CI = 0.20–0.93))、第三个 (OR = 0.22 (95%CI = 0.09–0.54) ))，以及鱼类的最高四分位数（OR = 0.39 (95%CI = 0.18–0.86)）；二十碳五烯酸 (EPA) 的第三个 (OR = 0.39(95%CI = 0.16–0.92)) 和最高四分位数 (OR = 0.44(95%CI = 0.19–0.98))；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。在第二个 (OR = 0.43 (95%CI = 0.20–0.93))、第三个 (OR = 0.22 (95%CI = 0.09–0.54)) 中观察到痴呆症的风险显着低于非痴呆症（MCI 加上认知正常） ，以及鱼类的最高四分位数（OR = 0.39 (95%CI = 0.18–0.86)）；二十碳五烯酸 (EPA) 的第三个 (OR = 0.39(95%CI = 0.16–0.92)) 和最高四分位数 (OR = 0.44(95%CI = 0.19–0.98))；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。在第二个 (OR = 0.43 (95%CI = 0.20–0.93))、第三个 (OR = 0.22 (95%CI = 0.09–0.54)) 中观察到痴呆症的风险显着低于非痴呆症（MCI 加上认知正常） ，以及鱼类的最高四分位数（OR = 0.39 (95%CI = 0.18–0.86)）；二十碳五烯酸 (EPA) 的第三个 (OR = 0.39(95%CI = 0.16–0.92)) 和最高四分位数 (OR = 0.44(95%CI = 0.19–0.98))；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。43 (95%CI = 0.20–0.93))、第三 (OR = 0.22 (95%CI = 0.09–0.54)) 和最高四分位数 (OR = 0.39 (95%CI = 0.18–0.86))；二十碳五烯酸 (EPA) 的第三个 (OR = 0.39(95%CI = 0.16–0.92)) 和最高四分位数 (OR = 0.44(95%CI = 0.19–0.98))；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。43 (95%CI = 0.20–0.93))、第三 (OR = 0.22 (95%CI = 0.09–0.54)) 和最高四分位数 (OR = 0.39 (95%CI = 0.18–0.86))；二十碳五烯酸 (EPA) 的第三个 (OR = 0.39(95%CI = 0.16–0.92)) 和最高四分位数 (OR = 0.44(95%CI = 0.19–0.98))；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。98)) 二十碳五烯酸 (EPA)；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。98)) 二十碳五烯酸 (EPA)；第二个 (OR = 0.39(95%CI = 0.18–0.84))、第三个 (OR = 0.30(95%CI = 0.13–0.70)) 和最高四分位数 (OR = 0.28(95%CI = 0.12–0.66))用于二十二碳六烯酸（DHA）；二十二碳五烯酸 (DPA) 的第三个 (OR = 0.36 (95%CI = 0.16–0.85)) 和最高四分位数 (OR = 0.42 (95%CI = 0.19–0.95))。结论：中年多吃鱼可能有助于预防痴呆。