A previously undescribed polyketide (1) and 3 known analogs (2-4) were obtained from cultures of the potato endophytic fungus Aspergillus carneus. The structures were elucidated on the basis of extensive nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 was further determined by electronic circular dichroism and optical rotation calculations. Compounds 1-4 showed moderate antifungal activity against plant pathogens. Compounds 1, 2, and 4 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells, with half-maximal inhibitory concentration values of 13.36, 30.16, and 51.47 µM, respectively. Compound 4 showed effective antioxidant activity.

之前未描述的聚酮化合物（1）和图3个的已知类似物（2 - 4）从马铃薯内生真菌的培养物中获得肉色曲霉。在广泛的核磁共振光谱数据的基础上阐明了结构。的绝对CON组fi guration 1由电子圆二色性和旋光性计算中进一步确定。化合物1 - 4表现出对植物病原体的中等抗真菌活性。化合物1，2，和4抑制脂多糖刺激的RAW264.7细胞中一氧化氮的产生，最大抑制浓度值分别为13.36、30.16和51.47 µM。化合物4显示出有效的抗氧化剂活性。