We diagnosed epitheliotropic T-cell lymphoma of the forestomachs in 2 aged, half-sibling, zoo-managed bontebok (Damaliscus pygargus pygargus). One bontebok also had mesenteric lymph node and cutaneous involvement. Both animals had a history of chronic abdominal distension and diminished body condition that resulted in euthanasia. At autopsy, both animals had marked ruminal distension with diffusely blunted ruminal papillae and reticular crests. In case 1, there was an increased amount and particle length of the ruminoreticular fibrous material with scant fluid, and a 2-cm diameter focus of cutaneous crusting adjacent to a mammary teat. In case 2, the rumen and reticulum were fluid-distended with decreased fibrous material. Histologically in case 1, the rumen, reticulum, omasum, and skin had intraepithelial nests and sheets of neoplastic small lymphocytes; in case 2, the rumen and reticulum had a similar neoplastic cell population. Immunohistochemically, neoplastic lymphocytes were immunoreactive for CD3 and negative for CD20, confirming the diagnosis of epitheliotropic T-cell lymphoma.

我们在 2 岁、半同胞、动物园管理的 bontebok ( Damaliscus pygargus pygargus）。一只 bontebok 也有肠系膜淋巴结和皮肤受累。两只动物都有慢性腹胀和身体状况恶化的病史，导致安乐死。尸检时，两只动物都有明显的瘤胃扩张，瘤胃乳头和网状嵴弥漫性变钝。在病例 1 中，瘤胃网状纤维物质的数量和颗粒长度增加，液体稀少，乳头附近的皮肤结痂直径为 2 厘米。在病例 2 中，瘤胃和网状体液体膨胀，纤维物质减少。病例 1 的组织学上，瘤胃、网状体、瓣球和皮肤有上皮内巢和片状肿瘤性小淋巴细胞；在案例 2 中，瘤胃和网状细胞具有相似的肿瘤细胞群。免疫组化，