Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides,The Journal of Organic Chemistry

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Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-12-29 , DOI: 10.1021/acs.joc.0c02436
Xiao-Qin Shen ₁ , Sui-Qian Wang ₁ , Dongfeng Fan ₂ , Xing-Guo Zhang _{1,

3} , Hai-Yong Tu ₁

Affiliation

A practical and efficient method for the synthesis of α-fluorothioacrylamide was developed from selective defluorinative sulfuration of trifluoropropanamides with disulfides. The N-chelation-assisted copper-catalyzed defluorination and sulfurization reactions feature excellent functional group tolerance and incorporation of both sulfur atoms of disulfides into acrylamides.

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