Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio),Environmental Science & Technology

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Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio)
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2020-12-29 , DOI: 10.1021/acs.est.0c06632
Yanbin Zhao _{1,

2} , Jiahui Liang ₁ , Haoyu Meng ₁ , Yue Yin ₃ , Huajun Zhen _{2,

3} , Xuehan Zheng ₁ , Haochun Shi ₁ , Xiuzhi Wu ₄ , Yao Zu ₄ , Bin Wang ₅ , Liuyin Fan ₆ , Kun Zhang _{1,

2}

Affiliation

Increasing rare earth element (REE) mining and refining activities have led to a considerable release of these substances into aquatic environment, yet the knowledge of their impacts on aquatic organisms is still limited. Here, we explored the developmental effects of 16 REEs (concentration ranged from 0.46 to 1000 mg/L) to zebrafish embryos and highlighted the adverse effects of lanthanum (La) and praseodymium (Pr). Among the multiple developmental parameters measured, the significant effects on swimming behavior and cardiac physiology were the most prominent. Transcriptomic analysis of La and Pr at concentrations of 1.1 to 10 mg/L revealed their rather uniform effects at molecular levels. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis revealed that among others, notch, glutamate, and serotonin signaling, as well as cardiac hypertrophy and cardiac muscle contraction, were significantly affected. These changes of neural signaling were consistent with behavior effects observed and supported by neurotransmitter changes and thus provide a reasonable molecular mechanistic explanation. Furthermore, increased DNA damage and apoptotic activity at high concentrations were observed, especially in the heart. They may contribute to explain the observed adverse morphological and physiological outcomes, such as pericardial edema. The effect concentrations observed in the present study were comparable to the concentrations of REE residues at highly contaminated sites (several mg/L), indicating ecotoxicological effects at environmentally relevant concentrations. Overall, the present data help to clarify the potential developmental toxicity of REEs that was not yet fully recognized and thus contribute to their environmental risk assessment.

中文翻译：

稀土元素镧和Pra对斑马鱼（Danio rerio）的神经和心血管发育产生不利影响

越来越多的稀土元素（REE）开采和提炼活动已导致这些物质大量释放到水生环境中，但是关于其对水生生物影响的知识仍然有限。在这里，我们探讨了16种稀土元素（浓度范围为0.46至1000 mg / L）对斑马鱼胚胎的发育影响，并着重指出了镧（La）和（Pr）的不利影响。在测得的多个发育参数中，对游泳行为和心脏生理的显着影响最为显着。对La和Pr在1.1至10 mg / L浓度下的转录组学分析表明，它们在分子水平上具有相当均匀的作用。京都基因与基因组百科全书（KEGG）途径分析表明，除了缺口，谷氨酸和5-羟色胺信号外，以及心脏肥大和心肌收缩均受到显着影响。神经信号的这些变化与观察到并受神经递质变化支持的行为效应是一致的，因此提供了合理的分子机理解释。此外，观察到高浓度的DNA损伤和凋亡活性增加，尤其是在心脏中。它们可能有助于解释观察到的不良形态和生理结果，例如心包水肿。在本研究中观察到的影响浓度可与高度污染地点的REE残留物浓度（几毫克/升）相比，表明在与环境有关的浓度下具有生态毒理作用。总体，

更新日期：2021-01-19

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