In a recent issue of Neurosurgery, the authors¹ test a hypothesis that the molecular profile of gliomas may significantly influence their anatomic and functional integration within language and motor networks.¹ Using a retrospective approach, they present data showing that gliomas characterized by mutations in isocitrate dehydrogenase (IDH) are more likely to involve, rather than displace, eloquent cortex and subcortical tracts, implying that these lesions may be less amenable to aggressive resection. This timely analysis incorporates modern World Health Organization brain tumor classification² with new observational data in patients undergoing craniotomy with intraoperative mapping for glial tumors.

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评论：神经胶质瘤网络接口：神经胶质瘤分子亚型与肿瘤内功能关系的综述

在最近一期的《神经外科》中，作者¹检验一个假设，即胶质瘤的分子特征可能显着影响其在语言和运动网络中的解剖和功能整合。¹使用回顾性方法，他们提供的数据表明，以异柠檬酸脱氢酶 (IDH) 突变为特征的神经胶质瘤更有可能涉及而不是取代雄辩的皮层和皮层下束，这意味着这些病变可能不太适合积极切除。这种及时的分析结合了现代世界卫生组织脑肿瘤分类²对接受颅骨切开术术中对胶质瘤进行标测的患者的新观察数据。