BACKGROUND While multiple new larger-bore aspiration catheters have been introduced for stroke thrombectomy, sizeable cohort outcome studies are lacking along with meaningful comparative studies to evaluate whether they represent a clinically relevant improvement compared to predecessors. OBJECTIVE To evaluate comparative angiographic and clinical outcomes between an 071 and 068 aspiration catheter. METHODS The authors reviewed an institutional thrombectomy database extracting the first 150 consecutive cases utilizing React 71 (Medtronic, Dublin, Ireland) with a comparison of background/demographic, procedural, angiographic, and clinical outcome variables to a cohort of patients treated with our previously most frequently utilized 0.068-inch aspiration catheter. RESULTS In our React 71 cohort, successful reperfusion (thrombolysis in cerebral infarction [TICI] 2b-3) was achieved in 95% of cases. In comparison to a prior cohort of 96 patients treated with a 0.068-inch catheter, there was no statistically significant difference in rates of successful reperfusion (TICI 2b-3), initial disposition, and 90-d outcome. However, the frequency of single pass cases was significantly higher in the React 71 cohort (47% vs 35%, P = .019 on multivariate analysis) along with the rate of TICI 2c-3 reperfusion after the first pass (26% vs 14%, P = .019 on multivariate analysis), and final TICI 2c-3 reperfusion (39% vs 28%, P = .04 on multivariate analysis). CONCLUSION While rates of TICI 2b-3 reperfusion and clinical outcome results were similar, our study suggests that a newer, larger bore aspiration catheter may be associated with a greater frequency of single pass cases and higher quality reperfusion, judged as TICI 2c-3 frequency after the first and final pass.

中文翻译：

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越大越好：使用 React 71 在再灌注方面向前迈进了一步

背景 虽然已经为中风血栓切除术引入了多个新的大口径抽吸导管，但缺乏大量的队列结果研究以及有意义的比较研究来评估它们是否代表与前辈相比的临床相关改进。目的 评估 071 和 068 抽吸导管之间的比较血管造影和临床结果。方法 作者回顾了一个机构血栓切除术数据库，该数据库使用 React 71（美敦力，都柏林，爱尔兰）提取了前 150 例连续病例，并将背景/人口统计学、程序、血管造影和临床结果变量与我们以前最常接受治疗的一组患者进行了比较。经常使用的 0.068 英寸抽吸导管。结果在我们的 React 71 队列中，在 95% 的病例中实现了成功的再灌注（脑梗塞溶栓 [TICI] 2b-3）。与之前使用 0.068 英寸导管治疗的 96 名患者队列相比，再灌注成功率 (TICI 2b-3)、初始处置和 90 天结果没有统计学显着差异。然而，React 71 队列中单次通过病例的频率显着更高（47% 对 35%，多变量分析 P = .019）以及第一次通过后的 TICI 2c-3 再灌注率（26% 对 14 %，多变量分析 P = .019）和最终 TICI 2c-3 再灌注（39% 对 28%，多变量分析 P = .04）。结论 虽然 TICI 2b-3 再灌注率和临床结果结果相似，但我们的研究表明，一种较新的、