Abstract

Synthetic cannabinoid metabolites with a 5F-4OH pentyl side chain are of great interest, and several synthetic methods have been developed for the synthesis of these types of metabolites in the literature, which is either lengthy or inappropriate for upscaling. Herein, a straightforward method has been developed and reported for the synthesis of a key intermediate in four steps with an overall yield of 49% on a multigram scale, and its application in the synthesis of nine potential metabolites of synthetic cannabinoids with a 5F-4OH pentyl side chain.

中文翻译：

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从可扩展的关键中间体合成9种潜在的具有5F-4OH戊基侧链的合成大麻素代谢物

抽象的

具有5F-4OH戊基侧链的合成大麻素代谢物引起了人们的极大兴趣，并且文献中已经开发了几种合成这些类型代谢物的合成方法，这些方法冗长或不适合用于大规模生产。在此，已经开发并报道了一种简单的方法，该方法可以分四个步骤合成关键中间体，以克数计的总收率为49％，并将其应用于合成具有5F-4OH的九种潜在大麻素的代谢产物戊基侧链。