Abstract

An efficient method is introduced based on the copper(II) acetate catalyzed one-pot multicomponent synthesis of novel chromeno[4,3-b]pyrano[3,4-e]pyridine-6,8-dione derivatives under mild reaction conditions in water as a “green” solvent. The synthesis involves the multicomponent reaction of 4-aminocoumarin, 6-methyl-2H-pyran-2,4(3H)-dione, and aldehydes in the presence of 10 mol% of copper(II) acetate as catalyst under mild reaction conditions. Eight different derivatives are synthesized using various benzaldehydes with different functional groups. All the produced chromeno[4,3-b]pyrano[3,4-e]pyridine-6,8-diones were synthesized successfully in very good isolated yields. A possible mechanism was proposed and presented. In general, the method is simple and is based on commercially available reagents and catalyst.

摘要

介绍了一种基于乙酸铜（II）催化一锅法多组分合成新型色烯并[4,3 - b ]吡喃并[3,4- e ]吡啶-6,8-二酮衍生物的有效方法。水作为“绿色”溶剂。该合成涉及 4-氨基香豆素、6-甲基-2 H-吡喃-2,4(3 H )-二酮和醛在 10 mol% 乙酸铜 (II) 催化剂存在下在温和反应下的多组分反应条件。使用具有不同官能团的各种苯甲醛合成了八种不同的衍生物。所有生产的铬烯[4,3- b ]吡喃[3,4- e]pyridine-6,8-diones 以非常好的分离收率成功合成。提出并提出了一种可能的机制。通常，该方法简单并且基于可商购的试剂和催化剂。