Study of volumetric, viscometric, and aggregation properties of losartan potassium and its interaction with amino acids and cetyltrimethylammonium bromide in aqueous solution,Journal of Physical Organic Chemistry

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Study of volumetric, viscometric, and aggregation properties of losartan potassium and its interaction with amino acids and cetyltrimethylammonium bromide in aqueous solution
Journal of Physical Organic Chemistry ( IF 1.9 ) Pub Date : 2020-12-28 , DOI: 10.1002/poc.4179
Muhammad Shakeel ₁ , Khalid Mahmood ₂

Affiliation

This manuscript reports volumetric, viscometric, and aggregation properties of losartan potassium (LP) in aqueous medium and its interaction with a cationic surfactant (cetyltrimethylammonium bromide [CTAB]). Densities of drug solutions were used to calculate apparent molar volumes while constants of Jones–Dole equation were calculated from viscosity measurements. By measuring surface tension, refractive index, and electrical conductivity of drug solutions, critical micelle concentration (CMC) of drug was determined, and calculation of surface excess concentration, free energy change of adsorption, free energy change, entropy change, and enthalpy change of micellization was carried out. UV/Visible spectroscopic data were used to get an understanding about the interaction of drug with cationic surfactant (CTAB). This interaction gives an idea about the interaction of drug with biomembrane as micelles of surfactant are similar to membranes in structure. The data were also used to calculate different important parameters for drug–surfactant interaction such as partition coefficient and binding constant. Moreover, two amino acids (glycine and l‐tryptophan) were used in solutions of drug separately to change its CMC. The results from volumetric and viscometric studies showed that the presence of drug in solution resulted in more organization of solvent molecules due to hydrophobic interaction. From the values of ∆G°_ads and ∆G°_m, it was concluded that the adsorption of drug molecules at solution–air interface and formation of micelles occurred spontaneously. A strong drug‐surfactant (LP–CTAB) interaction was observed by the attachment of drug molecules onto micellar surface of surfactant. The presence of amino acids in the solution of drug caused a decrease in the CMC of LP.

中文翻译：

氯沙坦钾的体积，粘度和聚集特性及其与氨基酸和十六烷基三甲基溴化铵在水溶液中的相互作用的研究

该手稿报告了氯沙坦钾（LP）在水性介质中的体积，粘度和聚集特性，以及其与阳离子表面活性剂（十六烷基三甲基溴化铵[CTAB]）的相互作用。药物溶液的密度用于计算表观摩尔体积，而琼斯-多尔方程式的常数由粘度测量值计算。通过测量药物溶液的表面张力，折射率和电导率，确定药物的临界胶束浓度（CMC），并计算表面过量浓度，吸附的自由能变化，自由能变化，熵和焓变。进行胶束化。紫外/可见光谱数据用于了解药物与阳离子表面活性剂（CTAB）的相互作用。这种相互作用给出了关于药物与生物膜相互作用的想法，因为表面活性剂的胶束与膜的结构相似。数据还用于计算药物与表面活性剂相互作用的不同重要参数，例如分配系数和结合常数。此外，还有两个氨基酸（甘氨酸和l-色氨酸）分别用于药物溶液中以更改其CMC。体积和粘度研究的结果表明，由于疏水作用，溶液中药物的存在导致溶剂分子的组织更多。从ΔG° _ads和ΔG° _m的值可以得出结论，药物分子在溶液-空气界面的吸附和胶束的形成是自发发生的。通过将药物分子附着到表面活性剂的胶束表面上，观察到了很强的药物表面活性剂（LP-CTAB）相互作用。药物溶液中氨基酸的存在导致LP的CMC降低。

更新日期：2020-12-28

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