The bitter tastant denatonium benzoate has no influence on the number of transient lower esophageal sphincter relaxations in health,Neurogastroenterology & Motility

当前位置： X-MOL 学术 › Neurogastroenterol. Motil. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The bitter tastant denatonium benzoate has no influence on the number of transient lower esophageal sphincter relaxations in health
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-12-29 , DOI: 10.1111/nmo.14061
Hannelore Geysen ₁ , Annelies Geeraerts ₁ , Wout Verbeure ₁ , Tim Vanuytsel ₁ , Jan Tack ₁ , Ans Pauwels ₁

Affiliation

Administration of a bitter compound can alter the intragastric pressure (IGP) after a meal. Additionally, a negative correlation between IGP and the number of transient lower esophageal sphincter relaxations (TLESRs) has been demonstrated. However, the effect of a bitter tastant on the number of TLESRs and subsequent reflux episodes has never been investigated and it is unclear whether bitter food items should be avoided in gastro-esophageal reflux disease. We hypothesize that bitter administration in healthy volunteers (HVs) will lead to an increase in the number of TLESRs.

中文翻译：

苦味剂苯甲酸地那铵对健康中短暂的下食管括约肌松弛次数没有影响

服用苦味化合物可以改变饭后的胃内压 (IGP)。此外，已经证明 IGP 与短暂的下食管括约肌松弛 (TLESR) 的数量呈负相关。然而，从未研究过苦味剂对 TLESR 次数和随后反流发作的影响，并且尚不清楚在胃食管反流病中是否应避免苦味食物。我们假设健康志愿者 (HV) 的苦味给药会导致 TLESR 数量增加。

更新日期：2020-12-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文