Photodynamic therapy (PDT) has recently gained attention as an alternative treatment of malignant gliomas. Glioblastoma (GBM) is the most prevalent within tumors of the central nervous system (CNS). Conventional treatments for this CNS tumor include surgery, radiation, and chemotherapy. Surgery is still being considered as the treatment of choice. Even so, the poor prognosis and/or recurrence of the disease after applying any of these treatments highlight the urgency of exploring new therapies and/or improving existing ones to achieve the definitive eradication of tumor masses and remaining cells. PDT is a therapeutic modality that involves the destruction of tumor cells by reactive oxygen species induced by light, which were previously treated with a photosensitizing agent. However, in recent years, its experimental application has expanded to other effects that could improve overall performance against GBM. In the current review, we revisit the main advances of PDT for GBM management and also, the recent mechanistic insights about cellular and molecular aspects related to tumoral resistance to PDT of GBM.

中文翻译：

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了解胶质母细胞瘤肿瘤生物学以优化光动力疗法：从分子到细胞事件

光动力疗法 (PDT) 最近作为恶性胶质瘤的替代疗法受到关注。胶质母细胞瘤 (GBM) 是中枢神经系统 (CNS) 肿瘤中最常见的。这种中枢神经系统肿瘤的常规治疗方法包括手术、放疗和化疗。手术仍被视为首选治疗方法。即便如此，应用任何这些治疗后疾病的不良预后和/或复发凸显了探索新疗法和/或改进现有疗法以实现彻底根除肿瘤块和剩余细胞的紧迫性。PDT 是一种治疗方式，它涉及通过光诱导的活性氧破坏肿瘤细胞，这些细胞之前用光敏剂处理过。然而，近年来，它的实验应用已经扩展到其他可以提高对抗 GBM 整体性能的效果。在当前的审查中，我们重新审视了 PDT 在 GBM 管理中的主要进展，以及最近关于 GBM 对 PDT 的肿瘤耐药性相关的细胞和分子方面的机制见解。