The present work aims to investigate release kinetics of a model drug (benzoic acid) loaded on silica aerogels from supercritical carbon dioxide (scCO₂). Effects of loading parameters on release kinetics have been analysed for two modes of drug loading: (i) only adsorption (mode I) at varying contact times and initial concentrations in scCO₂ and (ii) adsorption followed by precipitation (mode II) at varying initial concentrations and depressurization times. It is observed that drug loaded by mode II releases faster than mode I, both much faster than neat BA, though releases faster for both modes at lower initial concentration. Drug precipitated during fast depressurization releases faster than that during slow depressurization. Storage does not affect release kinetics for mode I at lower initial concentration, whereas storage slows down release for mode II. It is inferred that release is significantly enhanced and can be altered by varying the mode and loading conditions.

本工作旨在研究超临界二氧化碳（scCO ₂）负载在二氧化硅气凝胶上的模型药物（苯甲酸）的释放动力学。已针对两种载药模式分析了载量参数对释放动力学的影响：（i）仅在变化的接触时间和scCO _2中的初始浓度下吸附（模式I）（ii）吸附，然后在不同的初始浓度和减压时间下沉淀（模式II）。观察到，由模式II加载的药物比模式I释放更快，两者都比纯净BA快得多，尽管两种模式在较低的初始浓度下释放都更快。快速降压过程中沉淀的药物比缓慢降压过程中释放的药物释放更快。在较低的初始浓度下，储存不会影响模式I的释放动力学，而储存会降低模式II的释放动力学。可以推断释放明显增强，可以通过改变模式和加载条件来改变释放。