Micro/nanofibers have been widely applied to mimic the fibrillary structure of collagen type I from a bionic point of view, however, the wavy structure of collagen fibers in biological tissues such as arteries and ligaments has hardly been fabricated. In this study, a universal method was developed to fabricate the crimped fibers of different biopolymers by controlling the relaxation of residual stress, allowing the resulting scaffold a stable nonlinear elasticity. The effects of the processing conditions such as pre-strain, temperature of plasticizer, and fixed contraction length on the crimped fiber structure have been investigated. The results suggested that an engineered nonlinear elasticity of the scaffolds can be tailored by tuning the crimped structure. Human umbilical vein endothelial cells (HUVECs) cultured on the mat with crimped fibers showed promoted cell adhesion and cell spreading. Crimped fibers might have a great potential for repairing tendons and soft connective tissue and for constructing of tissue-engineering vascular grafts.

从仿生学的观点来看，微纤维/纳米纤维已被广泛地用于模拟I型胶原的纤维结构，但是，几乎没有制造生物组织如动脉和韧带中的胶原纤维的波浪状结构。在这项研究中，开发了一种通用方法，通过控制残余应力的松弛来制造不同生物聚合物的卷曲纤维，从而使所得支架具有稳定的非线性弹性。研究了预应变，增塑剂温度和固定收缩长度等加工条件对卷曲纤维结构的影响。结果表明，可以通过调整卷曲的结构来调整支架的工程非线性弹性。用卷曲纤维在垫上培养的人脐静脉内皮细胞（HUVEC）显示出促进的细胞粘附和细胞扩散。卷曲的纤维可能具有修复肌腱和软结缔组织以及构建组织工程性血管移植物的巨大潜力。