To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [¹¹C]ABP688 PET binding potentials (BP_ND), which allows for quantification of mGluR5 availability. Undirected graphs were constructed for the entire cortex in 17 FCD patients and 33 healthy controls using inter-regional similarity of [¹¹C]ABP688 BP_ND. We assessed group differences in network integration between healthy controls and the ipsilateral and contralateral hemispheres of FCD patients. Compared to healthy controls, FCD patients showed reduced network efficiency and reduced small-world connectivity. The mGluR5 network of FCD patients was also less resilient to targeted removal of high centrality nodes, suggesting a less integrated network organization. In highly efficient hub nodes of FCD patients, we observed a significant negative correlation between local efficiency and duration of epilepsy only in the contralateral hemisphere, suggesting that some nodes may be more vulnerable to persistent epileptic activity. Our study provides the first in vivo evidence for a widespread reduction in cortical mGluR5 network integration in FCD patients. In addition, we find that ongoing epileptic activity may alter chemoarchitectural brain organization resulting in reduced efficiency in distant regions that are essential for network integration.

为了确定与局灶性皮质发育异常（FCD）相关的5型代谢型谷氨酸受体（mGluR5）网络异常的程度，我们对[ ¹¹ C] ABP688 PET结合电位（BP _ND）进行了图论分析，从而可以量化mGluR5的可用性。使用[ ¹¹ C] ABP688 BP _ND的区域间相似性，为17位FCD患者和33位健康对照的整个皮质构建了无向图。我们评估了健康对照与FCD患者同侧和对侧半球之间网络整合的组差异。与健康对照组相比，FCD患者显示出较低的网络效率和较低的小世界连接性。FCD患者的mGluR5网络对高中心度淋巴结的靶向切除也缺乏弹性，这表明网络组织的整合程度较低。在FCD患者的高效枢纽结节中，我们仅在对侧半球观察到局部效率与癫痫持续时间之间存在显着的负相关性，这表明某些结节可能更容易遭受持续的癫痫活动。我们的研究为FCD患者皮质mGluR5网络整合的广泛减少提供了第一个体内证据。此外，