In this work, we have introduced a promising method for performing colon HCT-116 cancer cells treatment by the usage of CD44 to function as the targeting receptors. For this purpose, we have synthesized superparamagnetic Fe₃O₄/Mesoporous silica nanoparticles (MSNs) through co-precipitation and sol–gel process and had the surface of the obtained nanocarriers (NCs) functionalized by NH₂-bonding. The functionalized NCs have been characterized by the means of FT-IR spectroscopy, VSM, TEM, and FE-SEM. In the following, the values of drug loading and release have been measured through the application of ICP-OES analysis for 48 h, in which the drug release profile has been studied in both human blood (pH 7.4) and cancer cell (pH 5.0) conditions. According to the final results of MTT assay, the IC₅₀ of Free drug and NCs -drug loaded has faced a decrease, from 7.5 µg/mL to 3.2 µg/mL, due to the fact that NH₂ had been able to express a higher Oxaliplatin intracellular uptake and more CD44-binding than free Oxaliplatin. Therefore, this work has attempted to highlight these Fe₃O₄/MSNs-NH₂ NCs potential in standing as a superior candidate for Oxaliplatin loading and colon cancer treatment.

在这项工作中，我们介绍了一种有前途的方法，可通过使用CD44作为靶向受体来进行结肠HCT-116癌细胞的治疗。为此，我们通过共沉淀和溶胶-凝胶法合成了超顺磁性的Fe ₃ O ₄ /介孔二氧化硅纳米粒子（MSNs），并使所得的纳米载体（NCs）表面被NH ₂功能化。-粘接。通过FT-IR光谱，VSM，TEM和FE-SEM对功能化NC进行了表征。在下文中，通过应用ICP-OES分析48小时测量了药物负载和释放的值，其中已经在人血（pH 7.4）和癌细胞（pH 5.0）中研究了药物释放曲线条件。根据MTT分析的最终结果，由于NH ₂能够表达更高的浓度，游离药物和NCs药物的IC ₅₀值已从7.5 µg / mL降至3.2 µg / mL。奥沙利铂的细胞内摄取比游离奥沙利铂更能结合CD44。因此，这项工作试图突出这些Fe ₃ O ₄ / MSNs-NH ₂ NCs有潜力成为奥沙利铂载量和结肠癌治疗的最佳候选者。