Steroid-induced necrosis of femoral head (SINFH) is a femoral head necrotic disease caused by prolonged use of hormones. The detailed pathogenesis has not been fully demonstrated. In this study, we employed the bioinformatics approach to probe the roles of SINFH inhibitors. Core dysfunction modules related to SINFH was obtained. Meanwhile, GO and KEGG analysis of genes in dysfunction modules are carried out. Furthermore, the pivot prediction analysis of dysfunction modules related to ncRNA and transcription factor (TF) has been performed. The functions of the enriched modules were focused on multiple perspectives, including circulation, gland development, bone development and reconstruction, calcium production, and fatty acid metabolism regulation. The ncRNAs and TFs analysis showed that miR-322-5p, miR-124-3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. Drug targets suggested that Zinc and adenosine monophosphate may have an impact on SINFH dysfunction. SINFH was closely related to bone development and reconstruction.

激素性股骨头坏死（SINFH）是长期使用激素引起的股骨头坏死性疾病。详细的发病机制尚未完全阐明。在这项研究中，我们采用生物信息学方法来探索 SINFH 抑制剂的作用。获得了与SINFH相关的核心功能障碍模块。同时对功能障碍模块中的基因进行GO和KEGG分析。此外，还对与 ncRNA 和转录因子 (TF) 相关的功能障碍模块进行了枢轴预测分析。丰富模块的功能集中在多个角度，包括循环、腺体发育、骨骼发育和重建、钙生成和脂肪酸代谢调节。ncRNAs 和 TFs 分析表明 miR-322-5p、miR-124-3p、miR-125a-3p、和 Ctnnb1 是 SINFH 功能障碍的重要成员。药物靶点表明锌和一磷酸腺苷可能对 SINFH 功能障碍有影响。SINFH与骨骼发育和重建密切相关。