The world is going through the scourge of the COVID-19 pandemic since January 2020. However, the pandemic appears to be less severe in highly dengue endemic countries. In this connection, several studies reported that sero-diagnostic tests for dengue virus (DV) yielded considerable false-positive results for SARS-CoV-2 and vice versa in dengue endemic regions, thereby indicating towards potential cross-reactivity between these two viruses. We anticipated that SARS-CoV-2 and DV might share antigenic similarity and performed computational docking studies to test this hypothesis. Our results predicted with high confidence that human DV antibodies can indeed, bind to RBD of SARS-CoV-2 Spike protein. Some of these interactions can also potentially intercept human ACE2 receptor binding to RBM. Dengue serum samples predating the COVID-19, had been found to cross-react with SARS-CoV-2 Spike and this provides direct experimental validation of our predictions. Our analysis also showed that m396 and 80R antibodies (against SARS-CoV-1) did not dock with RBM of SARS-CoV-2, a fact already proven experimentally. This confirmed reliability and robustness of our approach. So, it is highly probable that immunological memory/antibodies to DV in endemic countries may reduce the severity and spread of COVID-19. It is not known whether SARS-CoV-2 antibodies will hinder DV infections by binding to DV particles and reduce dengue incidences in the future or, augment DV infection and severity by deploying antibody-dependent enhancement.

自2020年1月以来，世界正经历着COVID-19大流行的祸害。但是，在高登革热流行国家中，大流行似乎没有那么严重。在这方面，几项研究报告说，登革热病毒（DV）的血清诊断测试对SARS-CoV-2产生了相当大的假阳性结果，反之亦然在登革热流行区域中，这表明这两种病毒之间可能存在交叉反应。我们预计SARS-CoV-2和DV可能具有抗原相似性，并进行了计算机对接研究以验证这一假设。我们的结果高信度地预测，人DV抗体确实可以与SARS-CoV-2 Spike蛋白的RBD结合。这些相互作用中的一些也可能潜在地拦截人ACE2受体与RBM的结合。早于COVID-19的登革热血清样品已被发现与SARS-CoV-2 Spike发生交叉反应，这为我们的预测提供了直接的实验验证。我们的分析还显示，m396和80R抗体（针对SARS-CoV-1）未与SARS-CoV-2的RBM对接，这一事实已通过实验证明。这证实了我们方法的可靠性和鲁棒性。所以，在流行国家，DV的免疫记忆/抗体极有可能降低COVID-19的严重性和传播。尚不知道SARS-CoV-2抗体是否会通过与DV颗粒结合而阻碍DV感染并在将来减少登革热发病率，还是通过部署抗体依赖性增强作用来增加DV感染和严重程度。