A control theoretic three timescale model for analyzing energy management in mammalian cancer cells,Computational and Structural Biotechnology Journal

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A control theoretic three timescale model for analyzing energy management in mammalian cancer cells
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.csbj.2020.12.019
Abhijit Dasgupta ₁ , Abhisek Bakshi ₂ , Nirmalya Chowdhury ₃ , Rajat K De ₄

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Interaction among different pathways, such as metabolic, signaling and gene regulatory networks, of cellular system is responsible to maintain homeostasis in a mammalian cell. Malfunctioning of this cooperation may lead to many complex diseases, such as cancer and type 2 diabetes. Timescale differences among these pathways make their integration a daunting task. Metabolic, signaling and gene regulatory networks have three different timescales, such as, ultrafast, fast and slow respectively.

中文翻译：

用于分析哺乳动物癌细胞能量管理的控制理论三时间尺度模型

细胞系统的不同途径（例如代谢、信号传导和基因调控网络）之间的相互作用负责维持哺乳动物细胞的稳态。这种合作的失败可能会导致许多复杂的疾病，例如癌症和2型糖尿病。这些途径之间的时间尺度差异使得它们的整合成为一项艰巨的任务。代谢、信号传导和基因调控网络具有三种不同的时间尺度，分别是超快、快速和慢速。

更新日期：2020-12-29

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