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The ecology of plasmid-coded antibiotic resistance: a basic framework for experimental research and modeling
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.csbj.2020.12.027 Martin Zwanzig 1
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.csbj.2020.12.027 Martin Zwanzig 1
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Many antibiotic resistance genes are associated with plasmids. The ecological success of these mobile genetic elements within microbial communities depends on varying mechanisms to secure their own propagation, not only on environmental selection. Among the most important are the cost of plasmids and their ability to be transferred to new hosts through mechanisms such as conjugation. These are regulated by dynamic control systems of the conjugation machinery and genetic adaptations that plasmid-host pairs can acquire in coevolution. However, in complex communities, these processes and mechanisms are subject to a variety of interactions with other bacterial species and other plasmid types. This article summarizes basic plasmid properties and ecological principles particularly important for understanding the persistence of plasmid-coded antibiotic resistance in aquatic environments. Through selected examples, it further introduces to the features of different types of simulation models such as systems of ordinary differential equations and individual-based models, which are considered to be important tools to understand these complex systems. This ecological perspective aims to improve the way we study and understand the dynamics, diversity and persistence of plasmids and associated antibiotic resistance genes.
中文翻译：
质粒编码抗生素耐药性的生态学：实验研究和建模的基本框架
许多抗生素抗性基因与质粒相关。微生物群落中这些可移动遗传元件的生态成功取决于确保其自身繁殖的不同机制，而不仅仅是环境选择。其中最重要的是质粒的成本及其通过接合等机制转移到新宿主的能力。这些受到接合机制的动态控制系统和质粒-宿主对在共同进化中获得的遗传适应的调节。然而，在复杂的群落中，这些过程和机制会受到与其他细菌物种和其他质粒类型的各种相互作用的影响。本文总结了质粒的基本特性和生态原理，这对于理解水生环境中质粒编码的抗生素耐药性的持续存在特别重要。通过精选的实例，进一步介绍了常微分方程组和个体模型等不同类型仿真模型的特点，被认为是理解这些复杂系统的重要工具。这种生态视角旨在改善我们研究和理解质粒及相关抗生素抗性基因的动态、多样性和持久性的方式。
更新日期：2020-12-29
中文翻译：
质粒编码抗生素耐药性的生态学：实验研究和建模的基本框架
许多抗生素抗性基因与质粒相关。微生物群落中这些可移动遗传元件的生态成功取决于确保其自身繁殖的不同机制，而不仅仅是环境选择。其中最重要的是质粒的成本及其通过接合等机制转移到新宿主的能力。这些受到接合机制的动态控制系统和质粒-宿主对在共同进化中获得的遗传适应的调节。然而，在复杂的群落中，这些过程和机制会受到与其他细菌物种和其他质粒类型的各种相互作用的影响。本文总结了质粒的基本特性和生态原理，这对于理解水生环境中质粒编码的抗生素耐药性的持续存在特别重要。通过精选的实例，进一步介绍了常微分方程组和个体模型等不同类型仿真模型的特点，被认为是理解这些复杂系统的重要工具。这种生态视角旨在改善我们研究和理解质粒及相关抗生素抗性基因的动态、多样性和持久性的方式。
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