Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, if it becomes uncontrolled, inflammation may result in autoimmune or auto inflammatory disorders, neurodegenerative diseases or cancers. The currently available anti-inflammatory drug therapy is often not successful or induces severe side effects. Thus, the search of new therapeutic options for the treatment of inflammation is highly required. Medicinal plants have been an interesting source for obtaining new active compounds. Diarylheptanoids characterized by a 1, 7-diphenylheptane structural skeleton, are a class of secondary plant metabolites that have gained increasing interest over the last few decades due to a wide variety of biological activities. This review covers 182 natural linear or macrocyclic diarylheptanoids described in the period of 1982 to 2020 with anti-inflammatory activities evaluated using quantified in vitro and/or in vivo assays. All of these data highlight the pharmacological potential of these natural compounds to act as anti-inflammatory drugs.

涉及先天和适应性免疫系统的炎症是对感染的正常反应。然而，如果它不受控制，炎症可能会导致自身免疫性或自身炎症性疾病、神经退行性疾病或癌症。目前可用的抗炎药物疗法通常不成功或引起严重的副作用。因此，迫切需要寻找治疗炎症的新治疗方案。药用植物一直是获得新活性化合物的有趣来源。以 1, 7-二苯基庚烷结构骨架为特征的二芳基庚烷类化合物是一类次生植物代谢物，由于其广泛的生物活性，在过去的几十年中越来越受到关注。体外和/或体内试验。所有这些数据都突出了这些天然化合物作为抗炎药的药理学潜力。