Abstract

Nanodiamonds (NDs) were investigated as potential carriers of ^99mTc, which is widely used for the diagnosis of diseases in nuclear medicine. The sorption of ⁹⁹Tc(VII), ^99mTc(VII), and ^99mTc(IV) by commercial NDs and their reduced, aminated, and oxidized forms was studied. The physicochemical parameters of the Langmuir and Freundlich isotherms for the sorption of ⁹⁹Tc(VII) by the used ND samples were determined. The Sn(II): Tc(VII) ratio for the quantitative reduction of Tc to the oxidation state IV was optimized. It was shown that the initial (commercial) and oxidized NDs are promising carriers of ^99mTc(IV) for nuclear medicine.

中文翻译：

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用99,99m Tc同位素研究纳米金刚石对of的吸附行为

摘要

研究了纳米金刚石（NDs）作为^99m Tc的潜在载体，它被广泛用于核医学疾病的诊断。研究了工业ND对⁹⁹ Tc（VII），^99m Tc（VII）和^99m Tc（IV）的吸附及其还原，胺化和氧化形式。确定了用过的ND样品吸附⁹⁹ Tc（VII）的Langmuir和Freundlich等温线的理化参数。优化了将Tc定量还原为氧化态IV的Sn（II）：Tc（VII）的比例。结果表明，最初的（商业的）和氧化的NDs是有希望的核医学^99m Tc（IV）的载体。