We recently revealed that increases in particle sizes of very-low-density lipoproteins (VLDL) are highly correlated with the progression of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), and VLDL particle size may be a minimally invasive indicator of these hepatic disorders. Methionine and choline-deficient (MCD) diet fed animals are usually used as a NASH model; however, the application of this minimally invasive biomarker in MCD diet fed animals remains unclear. In the present study, we measured the levels of liver disease markers and plasma lipoprotein profiles in MCD diet fed rats, and compared them with those of normal diet fed rats. Assessing lipoprotein profiles showed marked increases in VLDL particle sizes in MCD diet fed rats with pathologically and biochemically NASH-like features.

我们最近发现，极低密度脂蛋白 (VLDL) 粒径的增加与非酒精性脂肪性肝病 (NAFLD)/非酒精性脂肪性肝炎 (NASH) 的进展高度相关，并且 VLDL 粒径可能是一种微创指标这些肝脏疾病。蛋氨酸和胆碱缺乏 (MCD) 饮食喂养的动物通常用作 NASH 模型；然而，这种微创生物标志物在 MCD 饮食喂养的动物中的应用仍不清楚。在本研究中，我们测量了 MCD 饮食喂养的大鼠的肝脏疾病标志物和血浆脂蛋白谱的水平，并将它们与正常饮食喂养的大鼠进行了比较。评估脂蛋白谱显示，在 MCD 饮食喂养的大鼠中，VLDL 颗粒大小显着增加，具有病理和生化 NASH 样特征。