Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

海洋海绵相关真菌是结构有趣且具有生物活性的次级代谢产物的有前途的来源。近年来，海绵相关真菌已发现大量天然产物。本文回顾了2010-2018年从与海绵相关的海洋真菌中分离的571种新化合物。这些分子包括八种不同的结构类别，包括生物碱，聚酮化合物，萜类化合物，类金属萜类化合物等。此外，大多数这些化合物具有深远的生物学活性，例如抗微生物，抗病毒，细胞毒性等。以及这些新型生物活性天然产物在药物研发中的未来潜力。