Owing to the growing demand for compelling antimicrobial agents, chalcones and their heterocyclic derivatives have engrossed prodigious attention of medicinal chemists as an effective clinical template for the synthesis of such agents on account of their structural diversity and molecular flexibility. Chalcones are considered as a fortunate scaffold in the field of both synthetic as well as natural product chemistry. They are reflected as a remarkable section of logically occurring pharmacophores that possess a comprehensive scale of biological activities, such as anti-cancer, anti-malarial, anti-viral and anti-inflammatory, rendering them with a high degree of assortment and noble therapeutic profile. They act as a crucial intermediate for the synthesis of novel heterocyclic skeletons holding biodynamic behavior. This review emphasizes on different aspects of chalcones including their natural sources, recent synthetic methodologies and evaluation of their anti-microbial potential. It is expected as a persuasive compilation on chalcones that may benefit the experts to design potent and less toxic chalcone referents as medicinal agents.

由于对引人注目的抗微生物剂的需求不断增长，查耳酮及其杂环衍生物因其结构多样性和分子灵活性而作为合成此类药物的有效临床模板引起了药物化学家的极大关注。在合成化学和天然产物化学领域，查耳酮均被视为幸运的支架。它们被反映为具有广泛生物活性（如抗癌，抗疟疾，抗病毒和抗炎）的逻辑活性药效团的显着部分，使其具有高度的分类性和高贵的治疗特性。它们充当合成具有生物动力学行为的新型杂环骨架的关键中间体。这篇综述着重介绍了查耳酮的不同方面，包括其天然来源，最新的合成方法以及其抗菌潜力的评估。可以作为有关查耳酮的有说服力的汇编，有望使专家们设计出有效且毒性较小的查耳酮指示物作为药物制剂。