The efficacy of Truong Xuan Cao Bang (TXCB), a Vietnamese herbal medicine prescription, on the quality of semen, serum testosterone (TES), and malondialdehyde (MDA) concentrations in rabbits whose reproductive ability were impaired by fluconazole was investigated. Mature male rabbits were randomly assigned into control (G1), fluconazole (G2), fluconazole and 180 mg/kg/day (G3), and 360 mg/kg/day TXCB (G4) groups. The reaction time (RT), ejaculate volume (EV), sperm concentration (SC), total sperm output (TSO), total sperm motility (TSM), progressive sperm motility (PSM), nonprogressive sperm motility (NPSM), sperm immobility (SIM), dead sperm (DS), and abnormal sperm (AS) levels were determined after TXCB administration. After 60 days, G3 showed a significant increase in serum TES and a significant decrease in the concentrations of serum MDA (SMDA) and seminal plasma MDA (SPMDA) compared with G1, in addition to increase in EV, SC, TSO, TSM, PSM, and serum TES, and decrease in RT, SIM, DS, AS, SMDA, and SPMDA compared with G2. G4 showed a steep rise in EV, SC, and serum TES and a downturn in DS, SMDA, and SPMDA compared with G1, and, compared with G2, a significant increase in EV, SC, TSO, TSM, PSM, and serum TES and a significant decrease in RT, SIM, DS, AS, SMDA, and SPMDA. Taken together, TXCB rehabilitates and simultaneously enhances spermatogenesis in rabbits whose reproductive ability was impaired by fluconazole.

研究了越南草药处方Truong Xuan Cao Bang（TXCB）对受氟康唑损害生殖能力的兔精液，血清睾丸激素（TES）和丙二醛（MDA）浓度的质量。将成年雄性兔随机分为对照组（G1），氟康唑（G2），氟康唑和180 mg / kg /天（G3）和360 mg / kg /天TXCB（G4）组。反应时间（RT），射精量（EV），精子浓度（SC），总精子产量（TSO），总精子活力（TSM），进行性精子活力（PSM），非进行性精子活力（NPSM），精子不动（在服用TXCB之后，确定了SIM（SIM），死精（DS）和异常精子（AS）的水平。60天后，与G1相比，G3的血清TES显着增加，血清MDA（SMDA）和精浆MDA（SPMDA）的浓度显着下降，此外EV，SC，TSO，TSM，PSM和血清TES有所增加，与G2相比，RT，SIM，DS，AS，SMDA和SPMDA减少。与G1相比，G4的EV，SC和血清TES急剧上升，DS，SMDA和SPMDA下降，与G2相比，G4的EV，SC，TSO，TSM，PSM和血清TES显着增加而RT，SIM，DS，AS，SMDA和SPMDA则显着下降。两者合计，TXCB可以恢复并同时增强氟康唑损害生殖能力的兔子的精子发生。和SPMDA与G2相比。与G1相比，G4的EV，SC和血清TES急剧上升，DS，SMDA和SPMDA下降，与G2相比，G4的EV，SC，TSO，TSM，PSM和血清TES显着增加而RT，SIM，DS，AS，SMDA和SPMDA则显着下降。两者合计，TXCB可以恢复并同时增强氟康唑损害生殖能力的兔子的精子发生。和SPMDA与G2相比。与G1相比，G4的EV，SC和血清TES急剧上升，DS，SMDA和SPMDA下降，与G2相比，G4的EV，SC，TSO，TSM，PSM和血清TES显着增加而RT，SIM，DS，AS，SMDA和SPMDA则显着下降。两者合计，TXCB可以恢复并同时增强氟康唑损害生殖能力的兔子的精子发生。