Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) is one of the adipokines associated with obesity, diabetes, and coronary heart disease. The association between plasma CTRP3 levels and AF is uncertain. The aim of this study was to investigate whether plasma CTRP3 concentrations were correlated with AF. Our study included 75 AF patients who underwent catheter ablation at our hospital and 47 sinus rhythm patients to determine the difference in plasma CTRP3 concentrations. Blood samples before the ablation were collected, and ELISA was used to measure the concentrations of CTRP3. Plasma CTRP3 concentrations were significantly lower in AF patients compared with control group ( vs. , ). In subgroup studies, patients with persistent AF had lower plasma CTRP3 concentrations than those with paroxysmal AF ( vs. , ). The concentrations of plasma CTRP3 in the recurrence group after radiofrequency catheter ablation of AF were lower than those in the nonrecurrence group ( vs. , ). Multivariate regression analysis revealed the independent correlation between plasma CTRP3 level and AF. Plasma CTRP3 concentrations were correlated with the presence of AF and AF recurrence.

中文翻译：

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心房颤动患者血浆 C1q/TNF 相关蛋白 3 (CTRP3) 的关联


心房颤动（AF）是一种非常普遍的心律失常，其特征是心房重构。补体 C1q 肿瘤坏死因子相关蛋白 3 (CTRP3) 是与肥胖、糖尿病和冠心病相关的脂肪因子之一。血浆 CTRP3 水平与 AF 之间的关联尚不确定。本研究的目的是调查血浆 CTRP3 浓度是否与 AF 相关。我们的研究纳入了 75 名在我们医院接受导管消融的 AF 患者和 47 名窦性心律患者，以确定血浆 CTRP3 浓度的差异。采集消融前的血样，采用ELISA法测定CTRP3的浓度。与对照组相比，AF 患者血浆 CTRP3 浓度显着降低（与对照组相比）。 , ）。在亚组研究中，持续性 AF 患者的血浆 CTRP3 浓度低于阵发性 AF 患者（与阵发性 AF 患者相比）。 , ）。房颤射频消融术后复发组血浆CTRP3浓度低于未复发组（vs）。 , ）。多变量回归分析揭示血浆CTRP3水平与AF之间的独立相关性。血浆 CTRP3 浓度与 AF 的存在和 AF 复发相关。