Bacterial infection is one of the main reasons for the clinical failure of oral titanium restorations. In this study, biodegradable polymer/TiO₂ nanotube nanoarray capsules were constructed on a titanium substrate surface to locally deliver drugs for long-lasting antibacterial properties. Anodization was applied to prepreparation TiO₂ nanotube array film on titanium substrate, and then, the upward opening TiO₂ nanotubes were sealed with biodegradable polymer (chitosan and polyethylene glycol) through electrochemical deposition. Scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) were used to analyze the characterization of this system. The drug release characteristics and the antibacterial activity demonstrated that the polymer coating significantly reduced burst release and enhanced lasting antibacterial properties. The nanoarray capsules still preserved integrity with a little degradation after 2 days. The strategy described herein provides a versatile route for designing targeted drug delivery systems in orthopaedical and other biomedical fields.

中文翻译：

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可降解的聚合物/ TiO2纳米管加载罗红霉素作为纳米阵列胶囊对钛植入物的持久抗菌性能

细菌感染是口腔钛修复体临床失败的主要原因之一。在这项研究中，可生物降解的聚合物/ TiO ₂纳米管纳米阵列胶囊被构建在钛基底表面上，以局部递送具有长效抗菌特性的药物。阳极氧化法用于在钛基底上制备TiO ₂纳米管阵列膜，然后向上开口TiO ₂通过可生物降解的聚合物（壳聚糖和聚乙二醇）将纳米管通过电化学沉积密封。使用扫描电子显微镜（SEM）和X射线光电子能谱（XPS）来分析该系统的特性。药物释放特性和抗菌活性表明，聚合物涂层显着降低了突释释放并增强了持久的抗菌性能。纳米阵列胶囊在2天后仍保持完整性，并有少许降解。本文所述的策略提供了在骨科和其他生物医学领域中设计靶向药物递送系统的通用途径。