Abstract

Aims

In patients with a history of chronic alcohol abuse, neurocognitive disorders (NCD) are not uncommon. The current study aimed to explore the course of cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA), and everyday cognitive functioning, as measured by the Patient Competency Rating Scale (PCRS), in a large group of patients with alcohol use disorder (AUD) admitted to the Center of Excellence for Korsakov and Alcohol-related Cognitive Impairments.

Methods

A multiple time-series design was used, in which the MoCA was administered at three time points of assessment, and the PCRS was completed by both the patient and a clinician at two time points, all during clinical treatment.

Results

A total of 524 patients were included, 71 of whom were diagnosed with AUD only, 284 with AUD and mild NCD (ARCI) and 169 with AUD, major NCD and fulfilling criteria for Korsakoff’s syndrome (KS).

Conclusions

Cognitive performance improved for all three groups during treatment, sustained abstinence and recovery from AUD. A low memory performance on the MoCA without improvement over time was predictive for KS, while improvement on this domain did not differentiate between AUD and ARCI. Changes in overall cognitive performance and orientation in patients with KS were positively related to changes in everyday cognitive functioning.

中文翻译：

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无、轻度或重度神经认知障碍的酒精使用障碍患者住院治疗期间的认知表现过程

摘要

宗旨

在有慢性酒精滥用史的患者中，神经认知障碍 (NCD) 并不少见。目前的研究旨在探索由蒙特利尔认知评估 (MoCA) 衡量的认知表现和由患者能力评定量表 (PCRS) 衡量的日常认知功能的过程，在一大群酒精使用障碍患者中(AUD) 被科萨科夫和酒精相关认知障碍卓越中心录取。

方法

使用多时间序列设计，其中 MoCA 在三个评估时间点进行，PCRS 由患者和临床医生在两个时间点完成，所有这些都在临床治疗期间。

结果

共纳入 524 名患者，其中 71 名仅诊断为 AUD，284 名诊断为 AUD 和轻度 NCD (ARCI)，169 名诊断为 AUD，主要 NCD 并符合 Korsakoff 综合征 (KS) 的标准。

结论

在治疗、持续戒断和从 AUD 中恢复期间，所有三组的认知能力都有所改善。MoCA 的低内存性能没有随着时间的推移而改善，可以预测 KS，而该领域的改善并没有区分 AUD 和 ARCI。KS 患者整体认知能力和方向的变化与日常认知功能的变化呈正相关。