ABSTRACT

This study investigated whether an optic neuropathy results in changes of brain glucose metabolism using 2-deoxy-2-F-18 fluoro-D-glucose (F-18 FDG) positron emission tomography (PET) scan. Optic nerves were crushed in the left eye of four male Sprague–Dawley rats, which were examined using F-18 FDG PET 7 days before and after surgery for a total of 5 weeks. We calculated the standardized uptake value ratio and analyzed relative changes in the visual cortex, thalamus, hypothalamus, and superior colliculus over time. The glucose metabolism in both visual cortices elevated after an optic nerve injury. A trend towards higher glucose metabolism, reaching significance 2 weeks following the procedure, was observed in the right visual cortical areas compared with those in the left hemisphere. The standardized uptake value ratios of both thalami significantly increased in 2 weeks as compared with the baseline. Other brain regions showed no significant changes. Traumatic optic neuropathy in rats causes asymmetrical elevation in brain glucose metabolism in the visual cortex, while the observed changes in the thalami as compared with baseline were similar in both hemispheres of the rat brain.

摘要

这项研究使用2-deoxy-2-F-18氟-D-葡萄糖（F-18 FDG）正电子发射断层扫描（PET）扫描研究了视神经病变是否会导致脑葡萄糖代谢的变化。在四只雄性Sprague-Dawley大鼠的左眼压伤视神经，在手术前后7天使用F-18 FDG PET对其进行检查，共5周。我们计算了标准摄取值比率，并分析了视皮质，丘脑，下丘脑和上丘随时间的相对变化。视神经损伤后，两个视皮层的葡萄糖代谢均升高。与左半球相比，在右视皮层区域观察到了更高的葡萄糖代谢趋势，该过程在术后2周达到了显着水平。与基线相比，两种海藻的标准摄取值比率在2周内显着增加。其他脑区无明显变化。大鼠的外伤性视神经病变会导致视觉皮层中脑葡萄糖代谢的不对称升高，而在大鼠脑的两个半球中，与基线相比，沙眼中观察到的变化相似。