Abstract

Reaction between 2-hydroxy-1,4-naphthoquinone and aroyl chlorides with potassium selenocyanate in the presence of catalytic amounts of N-methylimidazole under solvent-free conditions provided a simple and efficient one-pot route for the synthesis of 2-aryl-4-selenoxo-4H-naphtho[2,3-e][1,3]oxazine-5,10-diones. The reaction is characterized by mild conditions, short reaction time easy work-up, high yields of biologically active products and does not involve any hazardous solvent and tolerance to various functional groups.

中文翻译：

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高效一锅合成2-Aryl-4-Selenoxo-4H-Naphtho [2,3-e] [1,3] Oxazine-5,10-Diones

摘要

在无溶剂条件下，在催化量的N-甲基咪唑存在下，2-羟基-1,4-萘醌与芳酰氯与硒代氰酸钾的反应为合成2-芳基-4提供了一种简单有效的一锅法-selenoxo-4 H-萘[2,3- e ] [1,3]恶嗪-5,10-二酮。该反应的特征在于温和的条件，短的反应时间，易于后处理，高产率的生物活性产物，并且不涉及任何有害溶剂和对各种官能团的耐受性。