Abstract

The genus Salvia L. belongs to the Lamiaceae family including several known species rich in natural compounds that are extensively used in pharmaceutical, food, and cosmetic industries. Salvia multicaulis populations contain a broad diversity of flavonoids and phenolic acids. The present study aimed to explore biological and pharmacological effects including antimicrobial and antioxidant activities of nineteen S. multicaulis populations (SMPs) grown in Iran for the first time. High content of rosmarinic acid (RA) in SMP12 (Gazan) (5.65 ± 0.33 mg/g DW) caused high antimicrobial activity against two bacteria (Staphylococcus aureus, Escherichia coli) and the fungus Candida albicans, while methanolic extract of SMP1 (Taleghan) showed high antioxidant activity due to high content of salvianolic acid A (SAA) and quercetin (0.53 ± 0.04 and 0.49 ± 0.12 mg/g DW, respectively). Altogether these results can be considered for further commercial exploitations to meet the demands of the food and pharmaceutical industries.

摘要

Salvia L.属属于唇形科，包括几个已知的富含天然化合物的物种，广泛用于制药、食品和化妆品行业。Salvia multicaulis种群含有种类繁多的类黄酮和酚酸。本研究旨在探索首次在伊朗生长的 19 个S. multicaulis种群 ( SMP ) 的生物学和药理作用，包括抗菌和抗氧化活性。SMP12 (Gazan ) 中的高含量迷迭香酸 (RA) (5.65 ± 0.33 mg/g DW) 对两种细菌（金黄色葡萄球菌、大肠杆菌）具有高抗菌活性) 和真菌白色念珠菌，而SMP1 (Taleghan) 的甲醇提取物由于丹酚酸 A (SAA) 和槲皮素含量高（分别为 0.53 ± 0.04 和 0.49 ± 0.12 mg/g DW）而显示出高抗氧化活性。总之，这些结果可以考虑用于进一步的商业开发，以满足食品和制药行业的需求。