Abstract

In this paper, a survival study across regions is designed by considering the relationship between the hazard time and the treatment effect with unrecognized heterogeneity which interacts with treatment. The log-rank test is employed for the unrecognized heterogeneity and its interaction with the treatment effect. The test statistic for the overall treatment effect is used to calculate the total sample size for a survival study and the criteria are also proposed to rationalize partition sample size to each region.

中文翻译：

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考虑未识别异质性和治疗相互作用的生存分析样本量问题

摘要

在本文中，通过考虑危险时间与治疗效果之间的关系以及与治疗相互作用的未被识别的异质性，设计了一项跨区域的生存研究。对数秩检验用于未识别的异质性及其与治疗效果的相互作用。总体治疗效果的检验统计量用于计算生存研究的总样本量，并且还提出了标准以合理划分每个区域的样本量。