Cover illustration GPCRs and heterotrimeric G Proteins define the Hallmarks of Cancer. They act as cancer drivers by dysregulating oncocrine cellular signalling networks within and outside the tumor microenvironment. GPCR is schematized in pink, heterotrimeric G proteins in blue (Ga) and green (Gbg), the membrane in pale orange. Figure adapted from Hanahan and Weinberg, Cell, 2011 and modified from SMART (Servier Medical Art), licensed under a CC BY 3.0, and taken from “G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers” by N. Arang and J.S. Gutkind (pp. 4201–4232).

中文翻译：

---

封面

封面插图GPCR和异三聚体G蛋白定义了癌症的标志。它们通过使肿瘤微环境内外的癌旁细胞信号网络失调而充当癌症驱动器。GPCR以蓝色（Ga）和绿色（Gbg）中的粉红色，异源三聚体G蛋白，浅橙色的膜表示。该图改编自Hanahan和Weinberg，Cell，2011，改编自SMART（Servier Medical Art），经CC BY 3.0许可，取自N. Arang和JS的“作为癌症驱动力的G蛋白偶联受体和异三聚体G蛋白”古特金德（第4201–4232页）。