Polyelectrolyte complex nanoparticles with integrated advances of coacervate complexes and nanomaterials have attracted considerable attention as soft templates and functional nano‐carriers. Herein, a facile and robust strategy, namely electrostatic assembly directed polymerization (EADP), for efficient and scalable preparation of stable coacervate nanoparticles is presented. With homo‐polyelectrolyte PAA (polyacrylic acid) as template and out of charge stoichiometry, the cationic monomers are polymerized together with cross‐linkers, which creates coacervate nanoparticles featuring high stability against salt through one‐pot synthesis. The particle size can be tuned by varying the cross‐linker amount and salt concentrations during the polymerization and the composition of nanoparticles, as well as the corresponding properties can be regulated by combining different charged blocks from both strong and weak ionic monomers. The strategy can tolerate both high monomer concentrations and increased volume of up to l L, which is favorable for scaled‐up preparations. Moreover, the coacervate nanoparticles can be freeze‐dried to produce a product in powder form, which can be redispersed without any effect on the particle size and size distribution. Finally, the obtained nanoparticles loaded with enzyme and Au nanoparticles exhibit enhanced catalytic performance, demonstrating a great potential for exploring various applications of coacervate particles as soft and functional nano‐carriers.

中文翻译：

---

静电组装定向聚合高效合成稳定的聚电解质复合纳米粒子

具有凝聚层复合物和纳米材料的综合进展的聚电解质复合物纳米颗粒作为软模板和功能性纳米载体已引起了相当大的关注。在此，提出了一种简便有效的策略，即静电组装定向聚合（EADP），用于高效，可扩展地制备稳定的凝聚层纳米粒子。以均聚电解质PAA（聚丙烯酸）为模板并且化学计量不超支，阳离子单体与交联剂一起聚合，形成了凝聚型纳米颗粒，通过一锅法合成对盐具有很高的稳定性。可以通过在聚合过程中改变交联剂的数量和盐浓度以及纳米粒子的组成来调节粒径，可以通过结合强和弱离子单体的不同带电嵌段来调节相应的性能。该策略既可以耐受高单体浓度，又可以耐受高达1 L的增加体积，这对于按比例放大的制剂而言是有利的。此外，凝聚层纳米颗粒可以冷冻干燥，制成粉末状产品，可以将其重新分散而不会对粒径和粒径分布产生任何影响。最后，所获得的负载有酶和金纳米颗粒的纳米颗粒表现出增强的催化性能，展示了探索凝聚层颗粒作为软和功能纳米载体的各种应用的巨大潜力。该策略既可以耐受高单体浓度，又可以耐受高达1 L的增加体积，这对于按比例放大的制剂而言是有利的。此外，凝聚层纳米颗粒可以冷冻干燥，制成粉末状产品，可以将其重新分散而不会对粒径和粒径分布产生任何影响。最后，所获得的负载有酶和金纳米颗粒的纳米颗粒表现出增强的催化性能，展示了探索凝聚层颗粒作为软和功能纳米载体的各种应用的巨大潜力。该策略既可以耐受高单体浓度，又可以耐受高达1 L的增加体积，这对于按比例放大的制剂而言是有利的。此外，凝聚层纳米颗粒可以冷冻干燥，制成粉末状产品，可以将其重新分散而不会对粒径和粒径分布产生任何影响。最后，所获得的负载有酶和金纳米颗粒的纳米颗粒表现出增强的催化性能，展示了探索凝聚层颗粒作为软和功能纳米载体的各种应用的巨大潜力。