Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity,European Journal of Neurology

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Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity
European Journal of Neurology ( IF 4.5 ) Pub Date : 2020-12-28 , DOI: 10.1111/ene.14703
Johan Virhammar ₁ , Anja Nääs ₂ , David Fällmar ₃ , Janet L Cunningham ₄ , Andrea Klang ₅ , Nicholas J Ashton _{6,

7,

8,

9} , Sven Jackmann ₁ , Gabriel Westman ₂ , Robert Frithiof ₁₀ , Kaj Blennow _{6,

11} , Henrik Zetterberg _{6,

11,

12,

13} , Eva Kumlien ₁ , Elham Rostami ₁₄

Affiliation

Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.
Department of Neuroscience, Rehabilitation Medicine, Uppsala University, Uppsala, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute, Clinical Neuroscience Institute, King's College London, London, UK.
NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.
Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden.

Neurological symptoms have been frequently reported in hospitalized patients with coronavirus disease 2019 (COVID-19), and biomarkers of central nervous system (CNS) injury are reported to be increased in plasma but not extensively studied in cerebrospinal fluid (CSF). This study examined CSF for biomarkers of CNS injury and other pathology in relation to neurological symptoms and disease severity in patients with neurological manifestations of COVID-19.

中文翻译：

脑脊液中中枢神经系统损伤的生物标志物在 COVID-19 中升高，并与神经系统症状和疾病严重程度相关

2019 年冠状病毒病 (COVID-19) 住院患者经常报告神经系统症状，据报道血浆中中枢神经系统 (CNS) 损伤的生物标志物增加，但未在脑脊液 (CSF) 中进行广泛研究。这项研究检查了脑脊液中中枢神经系统损伤的生物标志物，以及与 COVID-19 神经系统表现患者的神经系统症状和疾病严重程度相关的其他病理学。

更新日期：2020-12-28

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