Head‐to‐head comparison of amplified plasmonic exosome Aβ42 platform and single‐molecule array immunoassay in a memory clinic cohort,European Journal of Neurology

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Head‐to‐head comparison of amplified plasmonic exosome Aβ42 platform and single‐molecule array immunoassay in a memory clinic cohort
European Journal of Neurology ( IF 5.1 ) Pub Date : 2020-12-28 , DOI: 10.1111/ene.14704
Tomotaka Tanaka _{1,

2,

3} , Joyce Chong Ruifen ₁ , Ying-Hwey Nai ₂ , Chin Hong Tan _{1,

4} , Carine Z J Lim _{5,

6} , Yan Zhang ₅ , Mary C Stephenson ₂ , Saima Hilal _{1,

7} , Francis N Saridin ₁ , Bibek Gyanwali ₁ , Steven Villaraza ₁ , Edward G Robins _{2,

8} , Masafumi Ihara ₃ , Michael Schöll ₉ , Henrik Zetterberg _{10,

11,

12,

13} , Kaj Blennow _{10,

11} , Nicholas J Ashton _{10,

14,

15,

16} , Huilin Shao _{5,

6} , Anthonin Reilhac ₂ , Christopher Chen ₁

Affiliation

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Division of Psychology, Nanyang Technological University, Singapore, Singapore.
Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore.
Institute for Health Innovation and Technology, National University of Singapore, Singapore, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Singapore Bioimaging Consortium, Agency for Science, A*Star, Singapore, Singapore.
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
NIHR Biomedical Research Centre for Mental Health, Biomedical Research Unit for Dementia at South London, and Maudsley NHS Foundation, London, UK.

Various blood biomarkers reflecting brain amyloid‐β (Aβ) load have recently been proposed with promising results. However, to date, no comparative study amongst blood biomarkers has been reported. Our objective was to examine the diagnostic performance and cost effectiveness of three blood biomarkers on the same cohort.

中文翻译：

在记忆临床队列中扩增等离子体外泌体 Aβ42 平台和单分子阵列免疫测定的头对头比较

最近提出了各种反映脑淀粉样蛋白-β（Aβ）负荷的血液生物标志物，并取得了有希望的结果。然而，迄今为止，尚未报道血液生物标志物之间的比较研究。我们的目标是检查同一队列中三种血液生物标志物的诊断性能和成本效益。

更新日期：2020-12-28

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