Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility in the type of metabolism. This metabolic reprogramming is needed to cope with survival and with the energetic demands of the senescent program that include the increased secretion of senescence-associated secretory phenotype factors.

中文翻译：

---

细胞衰老对非免疫细胞和免疫细胞代谢途径的影响

许多细胞应激诱导细胞衰老和不同细胞类型中细胞增殖的不可逆停滞。尽管它们的分裂能力受阻，但衰老细胞具有代谢活性，并且与非衰老细胞相比具有不同的代谢表型。在衰老细胞中观察到的变化取决于细胞类型，并导致代谢类型的适应性灵活性。需要这种代谢重编程来应对生存和衰老程序的能量需求，包括增加衰老相关分泌表型因子的分泌。