Nerve conduction studies (NCS) are essential to assess peripheral nerve fiber function in research models of immune-mediated neuritis. However, the current lack of standard protocols and reference values impedes data comparability across models and studies. We performed a systematic review and subsequent meta-analysis of the last 30 years of NCS of immune-mediated neuritis in Lewis-rats. Twenty-six papers met the inclusion criteria for meta-analysis. Extracted data showed considerable heterogeneity of recorded nerve conduction velocity (NCV) and compound muscle action potential (CMAP). Studies also significantly differed in terms of technical, methodical, and data reporting issues. The heterogeneity of the underlying studies emphasizes the need for standardization when conducting and reporting NCS in rats. We provide normative values for NCS of the sciatic nerve of Lewis rats and propose seven items that should be addressed when NCS are performed when studying immune paradigms in Lewis rats.

神经传导研究 (NCS) 对于评估免疫介导的神经炎研究模型中的周围神经纤维功能至关重要。然而，目前缺乏标准协议和参考值阻碍了模型和研究之间的数据可比性。我们对过去 30 年 Lewis 大鼠免疫介导的神经炎 NCS 进行了系统回顾和后续荟萃分析。二十六篇论文符合荟萃分析的纳入标准。提取的数据显示记录的神经传导速度（NCV）和复合肌肉动作电位（CMAP）存在相当大的异质性。研究在技术、方法和数据报告问题方面也存在显着差异。基础研究的异质性强调了在大鼠中进行和报告 NCS 时标准化的必要性。我们提供了 Lewis 大鼠坐骨神经 NCS 的规范值，并提出了在研究 Lewis 大鼠免疫范式时进行 NCS 时应解决的七个问题。