The most extensively studied influence on adolescent conduct problem behaviors is peers, and the literature points to genetics as one source of individual differences in peer influence. The purpose of this study was to test the hypothesis that an environmental sensitivity genetic index comprised of DRD4, 5‐HTTLPR, and GABRA2 variation would moderate the association between peer and adolescent conduct problems. Latent growth modeling was applied to PROSPER project longitudinal data from adolescents and their peers. Results showed the hypothesis was supported; adolescents with more copies of putative sensitivity alleles were more strongly influenced by their peers. The interaction form was consistent with differential susceptibility in follow‐up analyses. Strengths and weaknesses of genetic aggregates for sensitivity research are discussed.

中文翻译：

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青少年和同伴行为问题之间的纵向联系以及敏感性遗传指数的调节

对青少年行为问题行为的最广泛研究的影响是同伴，文献指出遗传学是同伴影响中个体差异的一个来源。本研究的目的是检验环境敏感性遗传指数由DRD4、5 -HTTLPR和GABRA2组成的假设。差异会缓和同伴和青少年行为问题之间的关联。潜在增长模型应用于来自青少年及其同龄人的 PROSPER 项目纵向数据。结果表明该假设得到支持；具有更多假定敏感性等位基因拷贝的青少年受到同龄人的影响更大。交互形式与后续分析中的差异易感性一致。讨论了用于敏感性研究的遗传聚集体的优势和劣势。