The aim of this study was to evaluate the concentration of penicillin G in bone affected by antiresorptive agent-related osteonecrosis of the jaw (ARONJ) following a single preoperative dose of 10 million international units (6000 mg). ARONJ is a major concern in patients administered antiresorptive agents for conditions associated with pathologically increased bone resorption. Antibiotic therapy is a key component of most treatment approaches for ARONJ and penicillin based regimens, providing a cost effective therapy option with a favorable side effect profile, are administered most frequently. In this study, high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) was applied to evaluate penicillin G concentration in serum and bone samples of 19 patients suffering from ARONJ and undergoing surgical treatment under perioperative intravenous (IV) antibiotic therapy. Penicillin G bone concentrations were above the limit of detection (0.1 μg/g bone tissue) in 16 out of 19 samples, with a median concentration of 2.7 μg/g (range 0.1–8.8 μg/g). Penicillin G concentrations in intraoperative serum samples were above the limit of detection in all serum samples, with a median concentration of 116 μg/mL (range 1–232 μg/mL). Thus, considering bacteria frequently found in ARONJ lesions, penicillin G at levels providing adequate antimicrobial activity was detected in the serum and 16 out of 19 osteonecrotic lesions of patients suffering from ARONJ.

中文翻译：

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术前单次服用抗吸收剂相关骨坏死影响下颌骨中青霉素G的浓度

这项研究的目的是评估术前一千万国际单位剂量（6000毫克）后受抗再吸收剂相关性颌骨坏死（ARONJ）影响的骨中青霉素G的浓度。对于与病理性骨吸收增加有关的疾病，在服用抗吸收剂的患者中，ARONJ是一个主要问题。抗生素治疗是ARONJ和青霉素类疗法大多数治疗方法的关键组成部分，因此最常用的方法是提供具有良好副作用的具有成本效益的治疗方案。在这个研究中，高效液相色谱-串联质谱法（HPLC-MS / MS）用于评估19名患有ARONJ并在围手术期静脉（IV）抗生素治疗下接受手术治疗的患者的血清和骨样品中青霉素G的浓度。在19个样本中，有16个样本中的青霉素G骨浓度超过了检测极限（0.1μg/ g骨组织），中位浓度为2.7μg/ g（0.1-8.8μg/ g）。术中血清样本中的青霉素G浓度高于所有血清样本的检出限，中位浓度为116μg/ mL（范围为1–232μg/ mL）。因此，考虑到ARONJ病变中常见的细菌，