Abstract

Propargylamines are a versatile class of amine molecules which find broad applications in numerous fields such as medicinal chemistry and drug discovery research. A³-coupling reaction of terminal alkynes, aldehydes and secondary amines is an efficient route for the synthesis of biologically active propargylamines. Over the last decade, the utilization of magnetic nanomaterials as heterogeneous reusable catalysts has received considerable attention in organic chemistry. In this review, we focus on the synthesis and versatile application of magnetically recoverable nanocatalysts in A³-coupling reactions.

中文翻译：

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磁性纳米催化剂在A3偶联反应中的作用

摘要

炔丙基胺是一类通用的胺分子，在许多领域中都有广泛的应用，例如药物化学和药物发现研究。末端炔烃，醛和仲胺的^3-偶联反应是合成生物活性炔丙基胺的有效途径。在过去的十年中，磁性纳米材料作为多相可重复使用的催化剂的利用在有机化学中受到了相当大的关注。在这篇综述中，我们专注于磁性可回收纳米催化剂在A ³偶联反应中的合成和广泛应用。