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Indoor volatile organic compounds exposures and risk of childhood acute leukemia: a case-control study in shanghai
Journal of Environmental Science and Health, Part A ( IF 1.9 ) Pub Date : 2020-12-26 , DOI: 10.1080/10934529.2020.1861903
Yan Zhang 1 , Didi Chen 2 , Rong Shi 1 , Michihiro Kamijima 3 , Kiyoshi Sakai 4 , Ying Tian 1, 5 , Yu Gao 1
Affiliation  

Abstract

A case-control study was conducted to investigate the relationship between indoor air pollution and childhood acute leukemia (AL) in Shanghai. 97 cases and 148 gender-, age-, and residence-matched controls were included. Indoor air pollution was evaluated by questionnaires and quantitative measurement including 14 volatile organic compounds (VOCs) and nitrogen dioxide (NO2) in the homes of the two groups. The levels of individual VOCs, VOC families, TVOC (sum of the concentrations of the individual VOCs) and NO2 were compared between the two groups. Exposure to styrene and butyl alcohol were associated with an increased risk of childhood AL (styrene: odds ratio (OR)=2.33, 95% confidence interval (CI): 1.07-5.07; butyl alcohol: OR = 2.51, 95%CI: 1.19-5.28); 4th quartile of chlorinated hydrocarbons (OR = 2.52, 95%CI: 1.02-6.26) and 3rd quartile of TVOC (OR = 4.03, 95%CI: 1.06-6.81) had significant higher ORs for childhood AL compared with that in the lowest quartiles. Elevated levels of individual VOCs, VOC families and TVOC were also associated with self-reported risk factors. Our findings suggest that VOCs exposure was associated with an elevated risk of childhood AL, underscore that more attention should be paid to indoor air pollution as a risk factor of childhood AL.



中文翻译:

室内挥发性有机化合物的暴露与儿童急性白血病的风险:在上海的病例对照研究

摘要

进行了一项病例对照研究,以调查上海的室内空气污染与儿童急性白血病(AL)的关系。纳入97例病例和148例性别,年龄和居所匹配的对照。通过问卷调查和定量测量评估室内空气污染,包括两组家庭中的14种挥发性有机化合物(VOC)和二氧化氮(NO 2)。比较了两组中各个VOC,VOC家族,TVOC(各个VOC浓度之和)和NO 2的水平。暴露于苯乙烯和丁醇会增加儿童期AL的风险(苯乙烯:比值比(OR) = 2.33,95 %置信区间(CI):1.07-5.07;丁醇:OR  = 2.51,95 %CI:1.19-5.28);氯代烃的第4四分位数(OR  = 2.52,95 %CI: 1.02-6.26)和TVOC的第3四分位数(OR  = 4.03,95 %CI: 1.06-6.81)儿童AL的OR s高于最低的四分位数。个体VOC,VOC家族和TVOC水平的升高也与自我报告的危险因素有关。我们的发现表明,VOCs暴露与儿童AL的风险升高有关,强调应更多地注意室内空气污染作为儿童AL的危险因素。

更新日期:2021-01-28
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