Selenium (Se) is an essential micronutrient for human health that protects from oxidative damage. Se deficiency has been associated with the development of cardiovascular diseases (CVD).

In this study we aimed to investigate the association between Se status, CVD risk, cardio-metabolic and inflammatory markers in elderly population.

Se Plasma levels and inflammatory markers [neutrophil/lymphocyte ratio, serum C-reactive protein (CRP) levels and Copper/Zinc ratio (Cu/Zn)] were measured in 858 control subjects (mean age 73.4 ± 9.3) and 606 CVD patients (mean age 72.5± 8.7). A multivariate logistic regression was performed to evaluate the association between Se deficiency (Se< 60 μg/L) and the risk of CDV. In a subgroup of 46 CVD patients the gene expression of IL-1β, CCL5/RANTES, IL-6, IL-8, IL-10, platelet-derived growth factor-β (PDGFβ) and sirtuins in peripheral blood mononuclear cell (PBMC) were further examined.

Increased values of neutrophil/lymphocyte ratio, CRP levels and Cu/Zn ratio were observed in Se deficiency condition both in controls and in CVD patients. Moreover, enhanced gene expression of cytokines and chemokines such as IL1β, CCL5 and PDGF- β, and a downregulation of SIRT-1, SIRT-5, SIRT-6, SIRT-7 were found in PBMCs from CVD patients with Se deficiency. A multivariate logistic regression showed that Se deficiency was associated with an increased CVD risk (odds ratio = 1.946, 95% CI: 1.19–3.18, p < 0.01).

The current study revealed that Se deficiency is independently associated with CVD, and with elevated circulating inflammatory markers and affects the expression of cytokines, chemokines and sirtuins in PBMCs.

硒（Se）是对人体健康至关重要的微量营养素，可防止氧化损伤。硒缺乏与心血管疾病（CVD）的发展有关。

在这项研究中，我们旨在调查老年人中硒状态，CVD风险，心脏代谢和炎症标记之间的关联。

在858名对照受试者（平均年龄73.4±9.3）和606名CVD患者中测量了Se血浆水平和炎性标志物[中性粒细胞/淋巴细胞比，血清C反应蛋白（CRP）水平和铜/锌比（Cu / Zn）]。平均年龄72.5±8.7）。进行多因素logistic回归以评估硒缺乏症（Se <60μg/ L）与CDV风险之间的关系。在46例CVD患者的亚组中，外周血单核细胞（PBMC）中IL-1β，CCL5 / RANTES，IL-6，IL-8，IL-10，血小板衍生生长因子-β（PDGFβ）和沉默调节蛋白的基因表达）进行了进一步检查。

在对照组和CVD患者中，在硒缺乏状态下，嗜中性粒细胞/淋巴细胞比，CRP水平和Cu / Zn比值均升高。此外，在患有硒缺乏症的CVD患者的PBMC中，发现细胞因子和趋化因子如IL1β，CCL5和PDGF-β的基因表达增强，并且SIRT-1，SIRT-5，SIRT-6，SIRT-7的表达下调。多元logistic回归显示，硒缺乏与CVD风险增加有关（几率= 1.946，95％CI：1.13-3.18，p <0.01）。

目前的研究表明，硒缺乏症与CVD独立相关，并与循环炎症标记升高有关，并影响PBMC中细胞因子，趋化因子和沉默调节蛋白的表达。