Ticks are the primary vector of arboviruses in temperate climates worldwide. They are both the vector of these pathogens to humans and an integral component of the viral sylvatic cycle. Understanding the tick‐pathogen interaction provides information about the natural maintenance of these pathogens and informs the development of countermeasures against human infection. In this review, we discuss currently available information on tick‐viral interactions within the broader scope of general tick immunology. While the tick immune response to several pathogens has been studied extensively, minimal work centres on responses to viral infection. This is largely due to the high pathogenicity of tick‐borne viruses; this necessitates high‐containment laboratories or low‐pathogenicity substitute viruses. This has biased most research towards tick‐borne flaviviruses. More work is required to fully understand the role of tick‐virus interaction in sylvatic cycling and transmission of diverse tick‐borne viruses.

中文翻译：

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蜱病毒相互作用：当前的理解和未来的前景

蜱是全球温带气候中虫媒病毒的主要载体。它们既是这些病原体对人类的载体，也是病毒森林循环的一个组成部分。了解蜱-病原体相互作用提供了有关这些病原体自然维持的信息，并为制定对抗人类感染的对策提供了信息。在这篇综述中，我们在一般蜱免疫学的更广泛范围内讨论了目前关于蜱病毒相互作用的可用信息。虽然已经广泛研究了蜱对几种病原体的免疫反应，但很少有工作集中在对病毒感染的反应上。这主要是由于蜱传病毒的高致病性；这需要高度封闭的实验室或低致病性的替代病毒。这使大多数研究偏向于蜱传黄病毒。需要更多的工作来充分了解蜱病毒相互作用在多种蜱传病毒的森林循环和传播中的作用。