Diabetic Endotheliopathy is widely regarded as a principal contributor to cardiovascular disease pathogenesis in individuals with Diabetes mellitus. The endothelium, the innermost lining of blood vessels, consists of an extensive monolayer of endothelial cells. Previously regarded as an interface, the endothelium is now accepted as an organ system with critical roles in vascular health; its dysfunction therefore is detrimental. Endothelial dysfunction induces blood vessel damage resulting in a restriction of blood and oxygen supply to tissues, the central pathology of cardiovascular disease. Hyperglycemic conditions have repeatedly been isolated as a pivotal inducer of endothelial cell dysfunction. Numerous studies have since proven hyperglycemic conditions to significantly alter the gene expression profile of endothelial cells, with this being largely attributable to the post-transcriptional regulation of RNA-binding proteins. In particular, the RBP Quaking-7 has recently emerged as a crucial mediator of diabetic endotheliopathy, with great potential to become a therapeutic target.

糖尿病内皮病变被广泛认为是糖尿病患者心血管疾病发病机制的主要因素。内皮是血管的最内层，由广泛的单层内皮细胞​​组成。内皮以前被视为界面，现在被认为是在血管健康中起关键作用的器官系统。因此，它的功能障碍是有害的。内皮功能障碍引起血管损伤，导致组织的血液和氧气供应受限，这是心血管疾病的中心病理。高血糖症已被反复分离为内皮细胞功能障碍的关键诱导因素。许多研究已经证明高血糖症会显着改变内皮细胞的基因表达谱，这主要归因于 RNA 结合蛋白的转录后调控。特别是，RBP Quaking-7 最近已成为糖尿病内皮病的关键介质，具有成为治疗靶点的巨大潜力。