Most traditional pesticide formulations contain environmentally unfriendly components and suffer from low utilization efficiency due to the loss, decomposition and burst release of active ingredients. Encapsulating pesticides using nanocarriers is a feasible approach to overcome these defects. In this work, the emamectin benzoate-loaded zein nanoparticles were fabricated by an antisolvent precipitation method combined with orthogonal experimental design. The mean size and zeta potential of the nanoparticles were 168 nm and 11.8 mV, respectively. The nano-delivery system could continuously release active ingredients, and exhibited the improved retention and bioavailability compared to traditional water dispersible granules. The one-step coprecipitation technique is simple, scalable and almost applicable to encapsulate all poorly soluble pesticides that have a certain solubility in ethanol solutions. The effective, sustained release and green nano-delivery system could significantly reduce the dosage and environmental pollution of pesticide, thereby improving ecological and economic effects.

大多数传统农药制剂都含有对环境有害的成分，并且由于活性成分的损失，分解和爆炸释放而导致利用率低下。使用纳米载体封装农药是克服这些缺陷的可行方法。在这项工作中，通过抗溶剂沉淀法结合正交实验设计，制备了载有依巴菌素的玉米醇溶蛋白玉米醇溶蛋白纳米颗粒。纳米颗粒的平均尺寸和ζ电势分别为168nm和11.8mV。与传统的水分散性颗粒相比，纳米递送系统可以连续释放活性成分，并显示出改善的保留和生物利用度。一站式共沉淀技术很简单，可扩展性强，几乎适用于封装在乙醇溶液中具有一定溶解度的所有难溶性农药。有效，持续释放和绿色纳米传递系统可以大大减少农药的用量和环境污染，从而改善生态和经济效益。