Background

Metabolic syndrome (MS) in lactating dams leads to several cardiometabolic changes related to selenium (Se) status and selenoproteins expression which produce hypertension. However, little is known about the state of these dams’ kidney functions and their Se deposits.

Methods

Two experimental groups of dam rats were used: control (Se: 0.1 ppm) and MS (Fructose 65 % and Se: 0.1 ppm). At the end of lactation (21d postpartum) kidney weight and protein content, Se deposits, and the activity of the antioxidant selenoprotein glutathione peroxidase (GPx) were measured in dams. Kidney functional parameters: albuminuria, creatinine clearance, serum aldosterone and uric acid levels and water and electrolyte (Na⁺ and K⁺) balance were also evaluated. Systolic blood pressure (SBP) was measured.

Results

In MS dams at the end of lactation Se deposits and GPx activity are higher in the kidney; however, lipid renal peroxidation appears, relative Se clearance increases, and the dams have lost Se by urine. MS dams have polyuria and polydipsia, high uric acid serum levels, albuminuria and high creatinine clearance, implying glomerular renal malfunction with protein loss. They also present hypernatremia, hypokalemia and hyperaldosteronemia, leading to high SBP; however, a natriuretic process is taking place.

Conclusion

Since these alterations appear, at least in part, to be related to oxidative stress in renal cells, Se supplementation could be beneficial to avoiding greater lipid renal oxidation during lactation.

中文翻译：

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妊娠和哺乳期间的代谢综合征：水坝的一个重要肾脏问题。硒肾清除率

背景

泌乳母猪的代谢综合征 (MS) 会导致与硒 (Se) 状态和硒蛋白表达相关的几种心脏代谢变化，从而导致高血压。然而，人们对这些水坝的肾功能状态及其硒沉积知之甚少。

方法

使用了两个实验组的大坝大鼠：对照（Se：0.1 ppm）和 MS（果糖 65% 和 Se：0.1 ppm）。在泌乳结束时（产后 21 天），测量母猪的肾脏重量和蛋白质含量、硒沉积物和抗氧化硒蛋白谷胱甘肽过氧化物酶 (GPx) 的活性。肾脏功能参数：还评估了白蛋白尿、肌酐清除率、血清醛固酮和尿酸水平以及水和电解质（Na ⁺和 K ⁺）平衡。测量收缩压（SBP）。

结果

在泌乳期末期的 MS 母猪中，肾脏中的硒沉积和 GPx 活性较高；然而，出现脂质肾过氧化，相对硒清除增加，母鼠通过尿液丢失硒。MS dams 有多尿和烦渴、高尿酸血清水平、白蛋白尿和高肌酐清除率，这意味着肾小球肾功能障碍和蛋白质丢失。它们还表现出高钠血症、低钾血症和高醛固酮血症，导致高收缩压；然而，正在发生一个利钠过程。

结论

由于这些变化似乎至少部分与肾细胞中的氧化应激有关，因此补充硒可能有助于避免哺乳期间肾脏发生更大的脂质氧化。